Tohoku Fukushi University

11年以前の主な研究業績等  【5点まで】

基本情報

氏名 土谷 昌広
氏名(カナ) ツチヤ マサヒロ
氏名(英語) Tsuchiya Masahiro

種類

学術論文

著書、学術論文等の名称

XBP1 may determine the size of the ameloblast endoplasmic reticulum.

単著・共著の別

共著

発行又は発表の年月

2008/11

発行所、発行雑誌等又は発表学会等の名称

J Dent Res. 87(11)

概要

Ameloblasts progress through defined stages of development as enamel forms on teeth. Pre-secretory ameloblasts give rise to tall columnar secretory ameloblasts that direct the enamel to achieve its full thickness. During the maturation stage, the ameloblasts shorten and direct the enamel to achieve its final hardened form. Here we ask how the volume of selected ameloblast organelles changes (percent volume per ameloblast) as ameloblasts progress through six defined developmental stages. We demonstrate that mitochondria volume peaks during late maturation, indicating that maturation-stage ameloblasts maintain a high level of metabolic activity. Also, the endoplasmic reticulum (ER) volume changes significantly as a function of developmental stage. This prompted us to ask if X-box-binding protein-1 (XBP1) plays a role in regulating ameloblast ER volume, as has been previously demonstrated for secretory acinar cells and for plasma cell differentiation. We demonstrate that Xbp1 expression correlates positively with percent volume of ameloblast ER.

ページ数等

1058-62.

【共・共著の場合のみ】共・共著者名

Tsuchiya M, Tye CE, Sharma R, Smith CE, Bartlett JD.